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KMID : 0620920230550061182
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Experimental & Molecular Medicine
2023 Volume.55 No. 6 p.1182 ~ p.1192
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Human induced neural stem cells support functional recovery in spinal cord injury models
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Daryeon Son
Jie Zheng
Kim In-Yong
Kang Phil-Jun
Park Kyoung-Min
Lia Priscilla
Hong Won-Jun
Yoon Byung-Sun
Park Gyu-Man
Yoo Jeong-Eun
Song Gwon-Hwa
Lee Jang-Bo
You Seung-Kwon
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Abstract
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Spinal cord injury (SCI) is a clinical condition that leads to permanent and/or progressive disabilities of sensory, motor, and autonomic functions. Unfortunately, no medical standard of care for SCI exists to reverse the damage. Here, we assessed the effects of induced neural stem cells (iNSCs) directly converted from human urine cells (UCs) in SCI rat models. We successfully generated iNSCs from human UCs, commercial fibroblasts, and patient-derived fibroblasts. These iNSCs expressed various neural stem cell markers and differentiated into diverse neuronal and glial cell types. When transplanted into injured spinal cords, UC-derived iNSCs survived, engrafted, and expressed neuronal and glial markers. Large numbers of axons extended from grafts over long distances, leading to connections between host and graft neurons at 8?weeks post-transplantation with significant improvement of locomotor function. This study suggests that iNSCs have biomedical applications for disease modeling and constitute an alternative transplantation strategy as a personalized cell source for neural regeneration in several spinal cord diseases.
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KEYWORD
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Neural stem cells, Spinal cord diseases
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